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It has been observed that the whole synthesis relies on 3 Ru-catalyzed reactions, (i) bis homopropargylic alcohol cycloisomerization to dihydropyran, (ii) DKR reduction of racemic-α aminoketone to fit two contiguous stereogenic centers, (iii) pyranol oxidation to get desired pyranol via Ru-catalyzed oxidation [43]
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Regular physical activity becomes even more critical during the maintenance phase
